In F9 cells, the effects of the retinoid are not dependent on de novo protein synthesis, while in Schwann cells, the presence of the protein synthesis inhibitor cycloheximide not only abolishes RXR-γ regulation but, in fact, it produces a strong decrease in mRNA levels, uncovering the existence of a labile activator of RXR-γ expression in Schwann cells.
An in vitro study of the expression profiling of miRNAs in steatotic human hepatocytes led to the identification of miR-10b as a new important regulator of steatosis levels, uncovering a novel mechanism for NAFLD pathogenesis [ 98].
Normal levels of liver enzymes, an increase in total antioxidant capacity and a decrease in lipid peroxidation level uncovered hepato-protective effects of these plants.
The modulation of the intrinsic APD heterogeneity due to electrotonic interactions at the tissue level uncovered here, and its further reduction during higher pacing frequencies, agree with the findings from previous simulation studies on more anatomically simplistic models (15, 20, 21, 42).
Focusing on the post-translocational state, we extended this assessment to the single-residue level, uncovering striking details of ribosome-ligand interactions and identifying both static and functionally important dynamic elements.
On a theoretical level, uncovering interactive mechanisms might explain the absence of hypothesized main effects of certain environments or might caution against 'one size fits all' intervention approaches.
Our analysis has quantified these discrepancies on a global level, uncovering many more cases where pairwise discrepancies are attributable to similar issues (Examples 4 6 in the Supplementary Discussion S3).
Isochores - long (>>300 kb), compositionally fairly homogeneous genome regions of different average GC levels were uncovered by analytical ultracentrifugation of bulk DNA [ 4- 10].
Beyond its impact on overall expression levels, we uncovered a connection between intragenic methylation in the paternal pronucleus and transcriptional variability that endures throughout the preimplantation embryo.
New research about how the virus works on the cellular level has uncovered what makes influenza so deadly: It destroys its host — you — by using your body's own defenses against itself.
