Your English writing platform
Discover LudwigSuggestions(1)
Exact(45)
Significantly higher levels of TRAIL, TRAIL R1, TRAIL R2 and TRAIL R4 were observed in synovial tissues from patients with active RA compared with normal controls (p < 0.05).
T cell lymphocytes of healthy control individuals expressed low levels of TRAIL and TRAIL receptors on the cell surface.
Increased expression of decoy receptors and decreased DR4/DR5 expression have been correlated with TRAIL resistance, although other studies indicated that the expression levels of TRAIL receptors do not correlate with TRAIL sensitivity.
However, it is known that expression levels of TRAIL receptors do not always correlate with the cell sensitivity to TRAIL cytotoxicity.
Previous study suggests the sensitivity to TRAIL therapy was not closely associated with the expression levels of TRAIL receptors in some types of cancer.
Expression levels of TRAIL receptors are indicated as the ratio between the mean fluorescence intensity of anti-TRAIL receptor-stained samples and that of isotype control-stained samples.
Similar(15)
Further screening of another breast cancer cell line, MDA-MB-231, revealed that low levels of TRAIL-R4 expression on surface were correlated with TRAIL sensitivity.
The latter finding is not surprising since many tumors that express high levels of TRAIL-R1 and/or TRAIL-R2 are resistant to soluble TRAIL [ 28– 328.
Tumor cells show elevated intracellular levels of TRAIL-R1/R2.
We also correlated the expression levels of TRAIL-receptor in OSCC with various clinicopathologic prognosticators.
Neither of the cell lines expressed detectable levels of TRAIL-R3 decoy receptor on surface.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com