For the genes RARB, RUNX1 and CDKN2B, we found that overexpression of the appropriate microRNA species (miR-15a and miR-20a, respectively) reduced protein levels of the respective gene products (Additional file 6: Figure S4).
We observed higher protein levels for PGC-1α, cytochrome c (Cycs) and the medium chain acyl-CoA dehydrogenase (MCAD) (Fig. 6) that reflect the higher transcript levels of the respective genes (Fig. 3A, 3D and 4A, respectively).
Treatment for 1 month reduced IgG class autoantibodies to dsDNA, ssDNA, and nucleosomes by 65%, 57%, and 81%, respectively, and after 2 months of treatment, the levels of the respective IgG autoantibodies were reduced by 37%, 66 %, 83, and 97%.
Values 0, 1 and 2 in x and y columns show the expression levels of the respective genes.
This algorithm was applied on a matrix compounded by the average levels of the respective statistical coefficients (for the entire interval 1989 2009).
where denotes the across-level difference between two maps at the center (c) and the surround (s) levels of the respective feature pyramids,,, ; ⊕ is across-level addition; is a normalization operator.
The levels of the respective metabolites were quantified using standard curves and the EMPOWER software.
Also, β-adrenergic receptor densitiy was decreased possibly due to reduced expression levels of the respective genes [45], [46].
Use of the siRNAs could knock down the levels of the respective proteins by 75% (data not shown).
In lysates of packaging cells, comparable expression levels of the respective proteins were determined independently from the presence or absence of the packaging and envelope expression constructs.
Although we found a core set of pathways across diseases, differences between disorders can arise due to different expression levels of the respective microRNAs.
