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From single AUD and VIS presentations, we were able to calculate sensitivity predictions, assuming different levels of summation, for all other stimulus presentation conditions.
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At each level of summation (preferred term, system organ class and overall), each patient was counted only once.
The exponent k signifies the degree of summation.
Moreover, since we carefully selected the OR probesets to avoid possible cross-reaction between similar ORs, the observed expression levels could not be a result of summation over numerous genes, each expressed in negligible amounts.
Figure 14 illustrates the accuracy of summation under fixed summarization levels in the ECBT project.
Figure 15 illustrates the accuracy of summation under empirical summarization levels in the ECBT project.
Figure 16 illustrates the accuracy of summation under algorithmic summarization levels in the ECBT project.
After summation of levels of all ESTs associated with the same enzyme, we found that the summative level of all enzymes tested was not greatly altered (i.e., fold change <2) upon ND except for acetyl-CoA oxidase (i.e., >twofold decrease) (Fig. 8b, for summative level of individual enzymes, see Additional file 8: Table S13).
This ranking exemplifies the increased level of convergence and summation needed to trigger neuronal events when one moves up the increasing complexity of the hierarchy of the nociceptive system.
An even stronger correlation (r = 0.61, P < 0.0001) was observed between the type I IFN chemokine score (summation of normalized levels of the four chemokines) and the global VAS score.
On the other hand, the Minkowski metric of summation has its roots in additive properties of low-level vision.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com