Sentence examples for levels of stimulatory from inspiring English sources

The differences between Matrigel®-GFR and ECMatrix™ assays could be explained by the fact that the levels of stimulatory cytokines and growth factors have been markedly reduced in the growth factor reduced Matrigel® to avoid problems associated with the over-stimulation of endothelial cells.

In this study, we have cultured murine bone marrow cells in the presence of IL-4 and GM-CSF to yield high-quality CD11b+ve CD8−veve CD8−ve myeloid mature DCs that express high levels of stimulatory MHC class II molecules, as well as CD80, CD86 and the chemokine receptor CXCR4.

To test the contribution of TNFα in capillary morphogenesis and to examine the role of certolizumab pegol on EC differentiation, we performed EC tube formation assays on growth factor-reduced Matrigel (Becton Dickinson Biosciences, Bedford, MA, USA) in which the levels of stimulatory cytokines and growth factors have been markedly reduced [ 27].

Alterations to the LCS structures are expected to impact how osteocytes perceive external mechanical stimulation during the "outside-in" mechnosensing processes by modulating the levels of stimulatory forces, such as fluid shear stresses and drag forces on the pericellular tethering fibers of osteocytes.

The activity of a particular IRES within a cell may be dependent on the relative level of stimulatory and inhibitory molecules [ 34].

Previous studies on Astragalus have suggested that treatment leads to (a) increased phagocytic activity of macrophages, (b) an increase in proinflammatory cytokines IL1, IL6 and TNF, and (c) an increase in levels of lymphocyte stimulatory IL2 and IL2 receptor expression [14], [21], [34], [35].

DBA mice have high levels of the stimulatory type III receptor on resting macrophages whereas cells from B10RIII mice have normal levels but show skewing in favor of type III over type IIb receptors upon triggering with inflammatory stimuli.

TLR9 agonists activate pDCs to secrete type I interferon (IFN) and to express increased levels of co-stimulatory molecules such as CD80 (B7.1) and CD86 (B7.2).

Mature DCs (mDC) express high levels of co-stimulatory molecules CD40, CD80 and CD86, which synergize with antigen in the activation of naïve T-cells.

At 4 dpi cDCs were sorted from both groups and expressed similar levels of co-stimulatory molecules (CD86) and MHCII and induced the same amount of T cell proliferation (Figure S1).

More importantly, the addition of the BMP antagonist Noggin was capable to restore the high levels of co-stimulatory molecule expression when DCs were co-cultured with NPCs and the BMP-secreting [33] ATDcondrogenicnic precursor cells only (Figure 8A C).