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Methylation levels of repetitive elements were determined using MethyLight technology as described previously [13].
We find that cancer cell lines in general have decreased methylation levels of repetitive elements.
BTBR is a minimally characterized inbred strain of mice that displays deficits in social behaviors and high levels of repetitive self-grooming, traits relevant to the first and third diagnostic symptoms of autism [40] [44].
By using CRoPS, polymorphism discovery will become affordable in organisms with high levels of repetitive DNA in the genome and/or low levels of polymorphism in the (breeding) germplasm without the need for prior sequence information.
BTBR has been proposed as a mouse model of autism, because of its low levels of sociability, juvenile play, and social transmission of food preference, and its high levels of repetitive self-grooming, resistance to change in a spatial habit in the Morris water maze, and poor shift performance in a holeboard task [40] [44], [66].
It has been suggested that an important factor in genome size reduction in birds has been that birds have lower levels of repetitive DNA than other vertebrates [ 10].
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We then examined the association between the respective chromosomal aberrations and the levels of repetitive-element methylation.
Bollati et al. also observed lower levels of repetitive-element methylation in MM, but they did not analyze methylation levels in MGUS [ 40].
As shown in Figure 1A, the mean levels of repetitive-element methylation were generally lower in MM than in MGUS, and the level in MGUS was lower than in NPC.
Each assembly line solution ensures an acceptable risk level of repetitive movements, as required by current law.
SNPs have been used to differentiate between clinical isolates and are preferred over the use of repeats for the construction of phylogenetic trees, because recombination events that could occur independently at the level of repetitive sequences are avoided [8].
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