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In addition, the CF lung lumen was shown to contain abnormal levels of nucleotides [127], glucose, and peptides [128].
Spotting assays on media containing 6-azauracil (6-AU) or mycophenolic acid (MPA), which both deplete intracellular levels of nucleotides leading to altered cellular viability when combined with mutations that affect transcriptional elongation, were completed.
During stress and apoptotic stimulation, when mitochondria-mediated ATP generation is compromised and the levels of nucleotides are reduced [16], procaspase-9 may stably associate with Apaf-1 apoptosome inhibiting caspase activation and apoptosis.
Growth arrest of RAS2val19, rim15Δ and other cells in S phase could be caused by a reduction in the levels of nucleotides and other factors required for efficient DNA synthesis, which would lead to replication stress.
The levels of nucleotides in cells will be altered significantly by perturbations provided by pharmaceuticals or environmental factors 12, 13.
In response to these conditions the levels of nucleotides rapidly fall, and this correlates with a complete replication arrest.
Similar(47)
All four candidate genes displayed different levels of nucleotide diversity, haplotype diversity and linkage disequilibrium.
To gain further insight into the evolutionary history and population dynamics of the wild subpopulations, we compared levels of nucleotide diversity and linkage disequilibrium (LD) decay among groups.
Compounds that elicited high levels of nucleotide exchange activity in vitro increased RAS-GTP levels in cells, and inhibited phospho ERK levels at higher treatment concentrations.
Both SPLTI-a and SPLTI-b are 98% identical to each other in both levels of nucleotide and amino acid sequence.
Different miRNA* sequences showed different levels of nucleotide divergence.
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