Observational studies provide a much closer reflection of the real world, but the very high levels of discontinuations suggest that many may not be due to statin-related events, and this has led to a number of studies investigating patterns of discontinuation and the causes.
In the Parisian center, there was no reason why women with poorer prognostic factors did not discontinue treatment, but the higher level of discontinuation could indicate that women with good prognostic factors also discontinued IVF treatment in the Parisian center.
Over a 2-year study, a relatively high level of discontinuation is to be expected; 56.1% (402/716) of patients received all 9 study treatments and 52.1% (373/716) received all study treatments and attended the final follow-up visit.
This level of discontinuation in trials in patients with schizophrenia does not appear to be particularly unusual (Mortimer, personal communication), and has been attributed to placebo-controlled study design (Kemmler et al. 2005).
Tolvaptan, a vasopressin V2 receptor antagonist, which is used to reduce cAMP-dependent fluid secretion, reduced the decline in kidney function in patients with ADPKD, but adverse effects led to a high level of discontinuation (Torres et al., 2012).
High levels of method discontinuation (45% of married women discontinue their method within the first 12 months of use) contribute to unmet need in Jordan.
The investigators' previous double-dummy clinical trial experience and the flexible treatment duration in Hokusai-VTE may have been two of the reasons that very low levels of patient discontinuation and withdrawal of consent were observed, as compared with the other VTE studies.
Large-scale epidemiologic studies describing patterns of cinacalcet use, effects on parathyroid hormone (PTH), calcium, and phosphorous levels, and predictors of discontinuation have not been previously reported.
Giusti et al (2004) observed in six of seven patients a significant decrease of CgA levels after discontinuation of omeprazole.
Of the eleven (73%) hypophosphatemic patients, all patients, except one, had normalization of serum phosphate levels after discontinuation of TDF.
