Sentence examples for levels of despair from inspiring English sources
Beyond that he views this second chance as an opportunity to prevent others from reaching such levels of despair.
An occupation determines so much about us: how we pass our days; our enemies and allies; our levels of despair or confidence.
"It's time there was a full royal commission into failings in the system that are driving so many people in our communities to such levels of despair that suicide is the only answer," he said.
This is the key concept of Franklin Zimring's amazing work on crime in New York; everyone said that, given the social pressures, the slum pathologies, the profits to be made in drug dealing, the ascending levels of despair, that there was no hope of changing the ever-growing cycle of violence.
Though later enlightened about their own levels of despair, they're at best a squealing bunch of parasuicides, and their rooftop farce and its ramifications becomes slapstick, all one-liners and wobbly furniture, with barely a glimmer of the mental pain required to underpin the decision to top themselves.
Until sentiment hits rock-bottom levels of "despair," there could be additional downside ahead.
Taken together these data strongly supporting a role for tonic activation of GluN2B-containing NMDARs in setting basal levels of despair-like behavior.
The tight correlation between mEPSC frequency and immobility times in the TST strongly supports our hypothesis that excitatory synapse number in PFC contributes to setting basal levels of despair-like behavior.
Thus, we propose that ambient glutamate suppresses protein synthesis in a GluN2B-dependent manner in order to maintain synapse number in cortical neurons and thereby contribute to setting levels of despair-like behavior.
If GluN2B-mediated signaling, specifically in principal cortical neurons, is directly involved in regulating levels of despair-like behavior in response to NMDAR antagonism we would expect the 2BΔCtx genetic mutation to both mimic and occlude the actions of ketamine.
These data generated from FST, TST, and EPM, both under basal conditions and in response to corticosterone treatment or chronic variable stress, strongly support the idea that GluN2B-mediated signaling, in cortical pyramidal neurons, is directly involved in setting basal levels of despair-like behavior in mice.
