Sentence examples for levels of deletions from inspiring English sources

Nevertheless, both Nested PCR and Long PCR indicated that these cells accumulate higher levels of deletions in the mtDNA as compared to those expressing p53R.

Most are S-cdG → A transitions, although S-cdG → T transversions and low levels of deletions of the 5′-neighbor dC are also observed.

Mean copy number of CDKN2A and CEP9 and frequency of nuclei with loss of PIK3CA were significantly different in the CM group compared with normal mucosa and marginal levels of deletions in TP63, FHIT, PIK3CA, EGFR, CDKN2A, YES and gains at PIK3CA, TP63, FGFR1, MYC, CDNK2A and NCOA3 were detected in few CM cases, mainly with dilation grades III and IV.

Based on these data, only 3% (1/31) of SN neurons from the elderly subjects harbour a clonally expanded point mutation, a very different scenario to mtDNA deletions, where high levels of deletions were detected in COX normal neurons from the same subjects (Table 1) and other elderly subjects (Bender et al., 2006; Kraytsberg et al., 2006).

Decreased levels of sequence homology and increased levels of deletion mutant heteroplasmy appear to correlate with earlier onset and more severe disease with multisystem involvement.

In contrast, levels of deletion mutant heteroplasmy showed a decreasing trend with increasing age, with group 1 having an average of 67.9% heteroplasmy, which is significantly higher than that of the other groups combined (42 53% average, P = 0.00069).

High levels of deletion have been detected in choroid plexus epithelial cells [78].

Even in the outlying sample (i.e. BCC, 89 y) the levels of deletion in the tumour and perilesional skin were similarly high at 13.4 and 14.9%, respectively.

For example, if salamanders' low levels of deletion events reflect fewer meiotic crossing-over events per bp, then genome expansion and DNA loss dynamics would mutually reinforce one another to bias genome sizes upward through the following steps: 1) transposable element proliferation increases genome size, whereas chromosome arm number remains constant.

The fact that groups B, C, D and E have varying level of deletions suggest each went through different deletion events.

Groups B through E contain partial aflatoxin gene clusters with varying level of deletions and Group F contains genotypes with none of the aflatoxin genes.