Sentence examples for levels of complements from inspiring English sources

In addition to C1q complement, serum levels of complements C3 and C4 are also decreased in SLE patients [ 24].

The titer of serum anti-C1q antibodies was positively correlated to anti-dsDNA antibodies (r = 0.796) and SLEDAI (r = 0.584) but inversely correlated to serum levels of complements C3 (r = −0.563) and C4 (r = −0.532) (Table 5).

Although both serum anti-dsDNA antibody and levels of complements (C3 and C4) alone displayed a superior sensitivity for identifying patients with active SLE and LN to anti-C1q antibodies, their specificities were inferior to anti-C1q antibody.

Importantly, a combination of anti-C1q and anti-dsDNA antibodies and/or serum levels of complements C3 and C4 leads to an increase of the specificity but decrease of the sensitivity for identification of SLE patients with active diseases and LN.

Such a lack of specificity of anti-dsDNA antibodies for renal flare was also observed in other conventional parameters such as anti-nucleosome antibody (ANA), levels of complements C3 and C4, proteinuria, and urine sediment [ 30], which led to searching other reliable immunological markers for identifying those SLE patients with active nephritis [ 16].

In this report, we evaluated the diagnostic value of serum anti-C1q alone or in combination with anti-dsDNA and/or serum levels of complements C3 and C4 for identification of patients with active SLE and LN in 95 SLE patients.

The increased number of activated microglia induced by the altered huntingtin protein most likely causes the higher levels of complement proteins in HD brains.

The initiation of BAL hemoperfusion was associated with a rapid decline in CH50 levels of complement and transient neutropenia and thrombocytopenia during all BAL exposures.

Variable levels of complement activation were detected two weeks post final boosting in RV144, which is when the V1V2 IgG correlate was identified.

Fig. 1 Brain mRNA expression levels of complement factors, complement inhibitors, and complement receptors evaluated by real-time PCR and expressed as fold changes relative to the control group.

Fig. 2 Brain expression levels of complement factors and complement inhibitors evaluated by immunoblotting, quantified by measuring band intensity with ImageJ, normalized by β-actin expression, and expressed as arbitrary units.*p < 0.05; ***p < 0.001.