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The optimal codon bias for a gene probably depends both on maintaining high levels of charged tRNAs and minimizing the levels of uncharged tRNAs which may inhibit translation and/or cause a deleterious metabolic response [38], [39], [41].
The presence of 3-AT also lowers the levels of charged histidyl-tRNA, inhibiting histidine biosynthesis [ 12].
Hence, the differential polysome sizes under the two conditions have allowed us to explore the effects of reducing the levels of charged histidyl-tRNA.
This is because, in addition to reducing ternary complex levels (like gcd mutations), 3-AT also reduces the levels of charged histidyl-tRNA by inhibiting histidine biosynthesis.
glp-4 (bn2 ts ) mutants, although germline deficient, very likely have partial inhibition of translation due to reduced levels of charged Val-tRNAval.
Studies of glp-4 (bn2 ts ) may thus contribute to understanding of how physiological perturbations (changes in levels of charged Val-tRNAval and/or protein translation) affect entrance and exit from adult reproductive diapause and used to model reformation of the polarized germline organization in adults that contain only a small stem cell population.
Similar(53)
Cars like the Nissan Leaf have individual sockets for the different levels of charging.
The water levels of charging blocks, though equal within a hill segment, is monotonically non-decreasing from one hill segment to the next.
Similar to off-peak charging, peak charging assumes a flat load curve with three levels of charging power to describe a certain number of EVs getting charged during the peak load time on the wholesale electricity market.
For the first methodology, efforts need to be made to produce the high-quality and defect-free 2D nanostructure which contains a minimum level of charged impurity density.
Electronic and optoelectronic devices designed for high level of charged particle radiation environments, such as artificial satellites, spacecraft, stations of nuclear energy and nuclear arms, have special design challenges to prevent damage mechanisms in these devices.
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