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In agreement with a fully functional macroautophagy-dependent degradation, levels of cargo receptors were slightly reduced in L2AKO mice livers (Fig. S2B).
A detailed analysis on protein expression levels for these peroxisomal proteins revealed a remarkable negative correlation between binding affinities and expression levels of cargo proteins, thus providing a mechanistic framework to generating a uniform population of Pex5p-cargo complexes necessary for proper peroxisomal biogenesis [ 28].
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But the precise level of cargo theft in Malaysia has proved hard to pin down.
Those figures give Malaysia the dubious distinction of having the second-highest level of cargo theft in the Asia-Pacific region after Hong Kong in terms of the value of goods stolen, according to the association's calculations.
The sleigh looks blocky like a Suburban, carries about the same level of cargo as much as C-5 might, yet has the speed of a fighter jet.
The peak level of cargo carried was in 1838 at 138,403 tons resulting in over £17,000 of tolls being paid.
Other work has shown that tubulation of ER-to-Golgi carriers is linked to the level of cargo expression (Simpson et al., 2006).
What mechanism could be at work is pure speculation at this point, but thoughts turn to there being a critical level of cargo, or a critical level of cargo interactions with early coat proteins leading to formation of an organized structure with multiple copies of several different proteins.
The amount of road (ton-kilometers) is affected by the level of cargos transported on roads and the length of trips.
The level of cargoes in the RER has in turn been shown to affect the number of ERES 58, 59.
This function requires both motor activity and C-terminal MT binding, and can be separated from the canonical vesicular and organelle trafficking function of UNC-116 both at the level of cargo-binding domains as well as the dependency on kinesin light chains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com