We performed a 'Mendelian Randomisation' analysis to test the likely causal relevance of circulating AMH levels on a broad range of human disease and health-related traits.
Indeed, an unbiased microarray screen has revealed that cyclic stretch can modulate the expression levels of a broad spectrum of microRNA in vitro, possibly contributing to stretch-associated alveolar epithelial cell dysfunction [37].
In 2005, the first metabolomic study of ALS reported reduced levels of a broad variety of metabolites in blood plasma although the results were inconclusive [10].
Standard untargeted metabolomic approaches typically report the static levels of a broad range of metabolites from unlabeled samples.
Comprehensive studies regarding levels of a broad spectrum of hormones in harbour porpoises have started recently and first results were published in a pilot study [ 9].
Collectively, these results provide molecular evidence that ZEB1 is required for the adipogenic transcriptional program by controlling mRNA levels of a broad range of genes during adipogenesis.
Currently, metabolomics approaches have enabled the parallel assessment of the levels of a broad range of metabolites and have had great value in both phenotyping and diagnostic analyses in plants [ 25].
The aim of this study was to explore the associations between the serum levels of a broad spectrum of T- and B-cell derived cytokines, growth factors and chemokines and 1-year radiographic progression in early RA patients.
Moreover, the high serum levels of a broad range of cytokines detected in these patients [ 34] suggest the involvement of multiple mediators in specific organ injury [ 8, 9, 39].
In the acute phase of SFTS human disease, the levels of a broad spectrum of serum cytokines, interleukin (IL -1RA, IL -1RAL-10, granulocyte colony-stimulating factor (G-CSF), interferon-γ-induced protein 10, and monocyte chemotactic protein-1, were elevated in SFTS patients and were present at higranulocyte in fatal cases compared to non-fatal cases.
