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Focal adhesion can be controlled by modulation of integrin expression levels, degradation of ECM structures by proteases, and focal contact disassembly by cytoskeletal reorganisation (reviewed by [ 69]).
It may be more beneficial to additionally target events that are upstream of apoptosis in OPMD pathogenesis, such as the aggregation of mutant PABPN1 and the levels (degradation) of mutant PABPN1.
(Note that the specific ordering depends on HSPG concentrations, protease levels, degradation rates, etc. Given their intrinsic variability in biological systems, the conclusion that a sufficiently strong matrix-binding isoform will have less matrix-bound VEGF is robust).
On the other hand, we do not find any additional data (such as quantitative measurement of chlorophyll levels, degradation products, or other senescence markers, such as enzymes or transcripts), which would provide a further insight documenting how alteration of bZIP63 levels modulate the starvation-induced and/or senescence responses.
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Then, model set order selection can be performed by trading between model set complexity and suboptimality level degradation.
For the vast majority of cases, the HPLC impurity profile provides much better (earlier and more sensitive) detection of low-level degradation products.
Chemical aging is the permanent molecular level degradation of fibres, resin or interfaces due to long-term exposure to the environment.
A combination of apathy among officials at the state level, degradation of the environment and the abandonment of traditional methods of water collection and storage has meant that water remains a scarce resource in much of the country.
We need to have a conversation, in general, about how women can't go anywhere on the Internet without suffering this constant low-level degradation and abuse (that occasionally flares up into alarming, high-level degradation and abuse) and how the way we've designed our technological systems aids and abets the social systems that are the real problem.
Antenna alignment mismatch test cases allow quantized link level degradation assessments, when the antennas are not aligned.
The side-lobe level degradation is more than 2 dB which can not satisfy the design requirements.
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