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Gene transcription levels and breadth of expression negatively correlate with the length of introns and the size of primary PK transcripts.
Transcription levels and breadth of expression negatively correlate with the length of introns and the size of primary transcript, which is likely due to the necessity to minimize metabolic costs of transcription for abundant mRNAs.
We show that architecture of regulatory PK genes significantly differs from other protein coding genes and explore relationships between gene structure, evolutionary conservation, transcript levels and breadth of gene expression.
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What factors determine the levels and breadths of gene expression?
In our multivariate multiple regression models, levels and breadths of expression together constitute dependent variables.
We identified several key genomic traits whose relative effects on levels and breadths of gene expression are quantified.
Secondly, in all significant predictors, the signs of coefficients are the same for both levels and breadths of gene expression.
Here, we show that we can predict substantial amount of variation in levels and breadths of gene expression using genomic information of each gene.
> -wrap-foot> > -wrap-foot> Our multivariate models explain between 7 and 14% of total variation in levels and breadths of gene expression (Tables 2 and 3).
Thus, we investigated effects of CpG O/E promoter and CpG O/E intron on levels and breadths of gene expression separately.
Together, levels and breadths of gene expression shape the diversity of organismal transcriptomes and eventually facilitate the development and the maintenance of complex biological systems.
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