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However, before escalating the dose to very high levels adherence should be assessed because as many of 50% of patients are noncompliant with the medication, 21 especially if they are having recurrent gout flares.
The AMPATH pediatric population generally reports very high levels adherence, particularly when monitored over a short period of time.[ 30] Thus, even a relatively small drop in ART adherence may have clinical significance when contrasted to the very high rates of adherence routinely reported.
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Clinic-level adherence measures were then calculated based on the proportion of OHA adherent patients within a clinic.
We identified 11 potential clinics based on diversity of clinic-level adherence rates and geography [ 33].
The average adjusted clinic-level adherence to OHAs was 70.7% and ranged from 57.5%to79.1%1%.
The amount of variation in clinic-level adherence explained by pharmacy bottleneck measures was 4.2%.
We analyzed associations between pharmacy measures and clinic-level adherence using linear regression.
Because taking medicine is a private affair, all individual-level adherence measurements are indirect.
Health centre-level adherence was computed as the mean of individual adherence to delivery at each centre.
Predicted clinic-level adherence was then obtained from the patient-level model using the mean characteristics for a given clinic.
To account for differences in patient characteristics across clinics that might influence clinic-level adherence scores, we risk adjusted clinic-level adherence scores using a hierarchical logistic regression model (see Wong, Piette et al. [ 17] for more details).
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