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The integration of the berry tissues "omic" data on all the pathways was divided into higher level pathway categories; the Cytoscape session files, molecular networks and a tutorial (Text S2) can be accessed and downloaded at the VitisNet tab at vitis-dormancy.sdstate.org.org
Gene numbers indicated the total gene numbers that assigned to each third level pathway.
This feature is the latest addition to the portal resources and its goal is to offer a systems level pathway view (revisit Figure 1B).
In this study, we examined the effects of in vitro exposure to either arsenic or cadmium in human TK6 lymphoblastoid cells using genomics and systems level pathway mapping approaches.
In the TSN with k = 4, the average Jaccard coefficient of the real common-motif, common-family, and common-tissue TF pairs was significantly higher than the random TF pairs by shuffling TSN 1000 times at the subpathway level, pathway level, and pathway class level (Table S10).
We analyzed the Jaccard coefficient to show that the functional consistency of subpathways regulated by the TF pairs with common motif, common family, or common tissue was significantly greater than the random TF pairs at the subpathway level, pathway level, and pathway class level.
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The third level pathways of group 1 and group 2 were list in the excel file.
The top three second level pathways were translation (154 genes) (Additional file 7), signal transduction (148 genes) (Additional file 8), and carbohydrate metabolism (122 genes).
The top three third level pathways were ribosome (20 genes) (Additional file 7), photosynthesis (Additional file 11) (7 genes), and protein processing in endoplasmic reticulum (6 genes).
The top three third level pathways were ribosome (76 genes) (Additional file 7), spliceosome (41 genes) (Additional file 9), and oxidative phosphorylation (36 genes) (Additional file 10).
The top three second level pathways were translation (26 genes) (Additional file 7), signal transduction (23 genes) (Additional file 8), and energy metabolism (16 genes).
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