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At present, there is only limited information about the cellular reactions of the host cells at the level of the proteome, especially with regard to recombinant protein secretion.
At the level of the proteome, the sets of homologs compiled with OrthoMCL were considered.
However, the extent to which this complexity is reflected at the level of the proteome remains unclear.
We hope that our data provide a strong stimulus to further explore C. elegans' immune response at the level of the proteome.
In this study we chose to look at the differences on the level of the proteome, lipid composition and physiological properties.
To gain further insight into the heat shock response of A. fumigatus at the level of the proteome, we applied 2D-fluorescence difference gel electrophoresis (DIGE).
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Steady state levels of the proteome depend on transcription, the levels of the transcripts, translation and protein degradation.
We can show the extent of pre-adaptation in the SS cells, especially at the level of the mitochondrial proteome.
Second, indels in conservative regions of proteins are probably too rare, even at the level of the whole proteome.
Of particular interest now will be to further study how these transcriptional crosstalks affect downstream processes, in particular at the level of the parasite proteome and metabolome.
Our approach provides an easy route to the characterization of UBA domain binding proteins at the level of the whole proteome, its application will unfold the important roles that p62's UBA domain plays.
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