Sentence examples for level of surrogate from inspiring English sources

The KELM model is adaptively trained during evolutionary search to satisfy desired fidelity level of surrogate so that it inhibits error accumulation of forecasting and results in correctly converging to true Pareto-optimal front.

We investigated the level of surrogate protective antibodies to the vaccine antigen in the serum of our vaccinees according to these criteria.

The target level of surrogates may not hold constant across different drugs (drug classes) or different patient groups, 18 19 since surrogates may have a continuous (instead of dichotomous) and other non-linear associations with the corresponding patient-centred outcomes.

Multiple treatment approaches have emerged, and the most attractive ones are the molecular-based therapies that can either restore the mutant dystrophin protein or enhance the levels of surrogate proteins.

We describe a new statistical method called the surrogate threshold effect (STE) that estimates the threshold level of a surrogate needed in a clinical trial to predict a benefit in the target clinical outcome.

The optimal biological dose can be defined as that which results in drug levels in the blood and/or tumour, which produced activity in preclinical models, the maximal change in the level of a surrogate marker or, if it can be measured directly, the desired clinical effect.

This was evidenced by expanding the original binary categorization of accepted/non-accepted surrogate for the CDR-specific analysis to the eventual ten-level categorization of surrogate acceptability.

Such endpoints may include plasma drug levels, measurement of surrogate markers for biological activity, or identification of drug target and subsequent target inhibiting dose.

To account for the lack of CO samples during earlier times, NIOSH/NCI used a second surrogate, HP (adjusted for usage), and divided by CFM (mine exhaust rate) to estimate levels of the surrogate CO.

In order to test whether high levels of the surrogate light chain could interfere with the maturation of early B cell stages, we set out to overexpress λ5 and VpreB1 in early B cells, using a λ5-IRES-VpreB1-EGFP retroviral expression vector (Figure 7A).

The relative levels of these surrogate tumour markers correlate with tumour burden.