FN1, MUC1, SCD and THBS1, appear more than once providing a level of signature validation.
This was not done in Cairo, it was not done in Beijing, it was not done in Copenhagen, and as far as I can see in the Conference decision, there is no decision at the Intergovernmental level of signature.
In this work, we apply the exponential decay in setting the signature, that is, we set the lengths for four levels of signatures, l1=16,l2=8,l3=6, and l4=4.
Compounds 3d and 3f also decreased the levels of signature extracellular matrix marker proteins (fibronectin, collagen, and α-smooth muscle actin) and representative mesenchymal cell markers (N-cadherin and vimentin).
In this cell background, inducible Rta modulated the levels of signature G1 arrest proteins, followed by induction of the cellular senescence marker, SA-β-Gal.
Weigelt et al. reported a method assigning prediction for each single patient based on correlation to "centroid" (a vector of mean expression levels of signature genes calculated for each subclass in training set) [17].
The ZmCEL2, ZmCEL6, ZmCEL19 and ZmCEL34 genes are transcribed chiefly in ovary and root, but, with the exception of ZmCEL2, display only background levels of signature tag abundance.
Ploidy duplication neither shifted the expression profile of a weakly metastatic cell to that of a highly metastatic one, nor obviously changed the expression levels of signature genes for highly metastatic cells.
All these validation studies clearly indicated that the regulatory network included relevant TF-target gene links to predict the expression levels of signature genes based on the expression profiles of TFs.
Still, as expected, the obtained regulatory network was highly predictive for the expression levels of signature genes in our astrocytoma data set used to learn the network (Additional file 2: Figure S7a).
