Exact(4)
Given the level of satellite coverage, are there really unmonitored black spots?
In eight of 10 mouse pancreatic tumors, the level of satellite transcripts was a stunning 40-fold higher than in normal mouse pancreatic cells, the team reports online today in Science.
Altogether, these data indicate that forced c-Flip expression leads to impaired regenerative potential that correlates with higher apoptosis level of satellite cells and reduced Pax-7 staining.
Indeed, even in wild-type mice, the expression level of satellite repeat in female PGCs is about three times higher than that in male PGCs (Supplementary information, Figure S4).
Similar(56)
Down the road, the high levels of satellite expression could help reveal how cancer develops.
Collectively, this expression comparison suggests that CD34+ cells transcribe higher levels of satellite cell characteristic genes than CD34− cells.
Pax7/Ki67 double stainings showed low levels of satellite cell proliferation similar to controls, while MyoD and Myogenin stainings showed undetectable satellite cell differentiation.
A previous report described low levels of satellite cell activation in classic infantile Pompe patients monitored 1 year after enzyme replacement therapy [ 34].
Our data suggest the defect is not at the level of the satellite cell, as the expression pattern of genes involved in satellite cell activation and differentiation are not altered, and myoblasts appear to fuse normally.
Interestingly, in the ADNP knockdown NIH3T3 cells the level of major satellite transcripts was also elevated compared to the cells treated with the scrambled control siRNA or untransfected (mock) cells (Figure 6D).
It will be underestimated, however, if there is any instance of sequence homogenization at the monomeric level of the satellite DNA in the lineage.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com