Your English writing platform
Discover LudwigSimilar(60)
Using cell lysates containing comparable levels of Rac expression and normalizing for total Rac levels, 2.5 3-fold more Rac activity is present in C8161.9 cells than M14 cells.
In a series of 37 patients, the levels of RAC 3 expression correlated significantly with tumour grade (P = 0.01) and stage of disease (P = 0.03) but not with serum PSA levels.
It is possible that in cells which endogenously express low levels of both Rac1 and -2, the threshold level of Rac activation downstream of LFA-1 engagement is not reached upon knockdown of either Rac isoform.
Thus, uniform activation of endogenous PI3K is sufficient to cause symmetry breaking and trigger migration while the symmetry breaking is lost at the level of Rac.
The mechanism by which cells are able to sense the relative level of Rac activity in neighboring cells remains unclear.
Extrapulmonary cardiac adverse effects (prolonged QTC interval) were not associated with the plasma level of rac-albuterol when administered by an inhaler in the emergency department setting.
Although we observed a striking, positive correlation between Tiam1 expression and cell motility in the panel of breast cancer cell lines, we did not observe a correlation between Tiam1 expression and overall levels of Rac activity.
Whereas total endogenous Rac protein expression remains equal among the cell variants, levels of Rac protein activity ranged from being highest in the most metastatic variant, medium in parental and medium metastatic variants, to least active in the least metastatic variant (Fig. 3a).
Alpha2M*-stimulated macrophages showed a marked elevation in the levels of Rac x GTP.
The total levels of Rac protein and Rac activity were measured and compared between C8161.9 and M14 cells.
Among panel members, no correlation was observed between total Rac expression and the expression of Tiam1 or Vav.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com