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Arrays marked with another protein, TetR-tdTomato, which has a propensity to form intramolecular dimers instead of intermolecular dimers, also display reduced level of pairing, supporting this idea.
This was consistent with the low level of pairing (4.5%) reported between chromosomes 4 and 10 in a previous study [24].
We designed probes to label euchromatic loci on chromosomes X and 2L, and we assessed the level of pairing by counting the number of FISH spots per nucleus.
As we demonstrate herein, a decreased level of pairing seems to improve correct repair (e.g., CAG slip-outs that may be random coils are repaired better than CTG hairpin slip-outs).
The number of Cid spots observed per cell is indicative of the level of pairing of homologous centromeric regions, with a lower number of Cid spots signifying a more paired state and a higher number signifying unpairing.
If the decreased level of intrastrand pairing of CAG slip-outs enhances their repair versus that of CTG slip-outs, it is possible that decreasing the level of pairing at the junction (by going from fully paired to up to two unpaired nucleotides) is what permits the improved repair of certain junction structures.
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The purpose of this paper is to study the effect of the level of Pair and the contraction of cross-section area (CSA) at the merging position on the flow energy merger and determine their optimum adjustments for a better merging process by using computation fluid dynamics (CFD).
As expected, the level of pair-wise LD as measured by r2 decreases with marker distance within each breed.
In (1) we formulated the differential equations up to the level of pairs and we said that this could be continued up to the full system level.
It is intuitively understood that clustering is at the root of problems with models based around closures at the level of pairs (Keeling and Eames 2005).
The co-expression level of paired bidirectional genes had been confirmed to be significantly higher than other neighbouring gene structures by whole-genome microarray data analysis [ 1, 5].
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