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Rather, levels of mechanisms are defined locally within a multilevel mechanism: one item is at a lower level of mechanisms than another when the first item is a part of the second and when the first item is organized (spatially, temporally, and actively) with the other components such that together they realize the second item.
Since changes in gene expression and regulation are involved in all remodeling processes, in the last years research has been dedicated to the investigation, at a molecular level, of mechanisms which could be altered during HF progression but could be also susceptible to recovery after mechanical assistance [ 7– 12].
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The dual acetylation of Lys9 and Lys14 along with Ser10 phosphorylation allows one-step higher level of mechanism for controlling gene regulation.
I think it an interesting subject for future work to establish the precise nature of any differences manifesting at the level of population dynamics, rather than at the incidental level, of mechanism.
With the current data, it is difficult to identify key downstream targets and that way describe the next level of mechanism of this process, as many targets are also widely used as segmentation markers.
One possibility is that such loss of effect occurs at the level of mechanism of activation and could reflect differences in receptor pharmacology, ephaptic transmission phenomena, etc. all specific to the positive allosteric modulation of the GABA alpha 1 subtype receptor.
Levels of mechanisms can thus be contrasted with levels of mere aggregation.
One implication of this view of levels, combined with certain familiar assumptions about causal relations, is that there can be no causal relationships between items at different levels of mechanisms.
Craver (2007) defines levels of mechanisms in terms of a relationship between the behavior (y) exhibited by a system (S) and the activity (f) of some component part (X) of that system.
As noted above, the fact that phenomena at higher levels of mechanisms depend upon the organization of component parts entails that the properties/activities of wholes are not simple sums of the properties/activities of the parts.
The ability to sort cell subpopulations of different sizes would facilitate investigation at genomic and proteomic levels of mechanisms by which cells attain and maintain their size.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com