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We then introduce several diagnostics aimed at quantifying both the level of intensification and diffusive mechanisms that lead to the intensification.
The four case studies contrasted in key systems characteristics: opportunism in decision making, i.e. flexible versus rigid crop rotations; function, i.e. production of livestock or crops; and level of intensification, i.e. dryland versus irrigated agriculture.
To examine the sensitivity of the findings to these assumptions, and to better understand the relationship between initial treatment decisions and the level of intensification administered through follow-up care, three additional clinical trials were simulated: Low-intensification case: patients not at goal were three times less likely to intensify treatment as in the main study.
This research should be planned and conducted in a systematic way to generate complementary data that allows an integrated evaluation of the regional level of intensification and correlated risks to human health over time, and thus a comprehensive tangible basis for the development of respective health promoting policies.
Another limitation is that we were unable to assess treatment intensification for A1C control in patients who were already taking insulin at the start of the study; it is possible that this causes underestimation of the level of intensification in this population and potentially biases differences in intensification rates for hyperglycemia by race/ethnicity.
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Further levels of intensification resulted in substantial reductions in FD without changes in species richness.
The decrease of FD was non-linear for specific leaf area and seed mass, with maximum reductions at intermediate levels of intensification.
The analysis suggests there are differences in the capability of different modelling approaches to assess changing levels of intensification: dynamic, process-based simulation models appear to be better suited to predict changes in land-use intensity than empirical, stochastic or static optimisation models.
The National Surgical Adjuvant Breast and Bowel Project (NSABP) examined the role of three levels of intensification of cyclophosphamide alone in the AC regimen (doxorubicin plus cyclophosphamide) in operable breast cancer patients with positive axillary nodes (Fisher et al, 1999).
The constant volume diafiltration method has the added advantage of being scalable and represents a high level of process intensification.
Agriculture intensity: The mean wheat yields per country (2012 data) were downloaded from FAOSTAT (Food and Agriculture Organization of the United Nations, http://faostat.fao.org/, accessed on 11/03/2014) and were used as a proxy for the level of agriculture intensification across Europe.
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