With the advent of intraoperative optimized planning, the treatment of prostate cancer with permanent implants has reached an unprecedented level of dose conformity.
There is no consensus on which level of dose is considered a 'low-dose' CT, however, the major screening trials used tube voltages between 90 kVp and 140 kVp and tube current in the range of 30 80 mAs [7].
With respect to the level of "dose constraints" [14] for radiological workers, the "break-even dose" might possibly serve as a natural reference for a large group of radiological workers. .
Hence, the optimum level of dose is 2 g/L (Daneshvar et al. 2003a, b; Grzechulska and Morawski 2002; Wang et al. 2009a, b; Rauf and Salman Ashraf 2009; Damardji et al. 2009; Chen et al. 2004).
It should be noted that despite an improvement in image quality with the ASiR-70 algorithm, median scores for diagnostic acceptability, subjective noise, spatial resolution and contrast resolution at this level of dose remained low.
For an experimental treatment with trichotomous levels, we derive the maximum likelihood estimator (MLE) of the risk ratio (RR) per level of dose increase in a RCT with noncompliance.
The literature analysis recommends to consider the volume of small bowel receiving 15 Gy (threshold of 100 to 200 cm3) but also 30 and 50 Gy (thresholds of 35 to 300 cm3, depending on the level of dose considered).
This enables clinicians to achieve a high level of dose conformity – i.e. ensuring the whole of the tumour receives an optimal level of radiation.
Moderate represents the moderate level of dosing of antidepressants.
