Sentence examples for level of deregulation from inspiring English sources

We anticipated that estrogen-responsive genes would be deregulated in response to E2 treatment and the level of deregulation would be partially suppressed or normalized when the anti-estrogen drug ICI is included in the E2 treatment since ICI is known to bind estrogen receptor monomers and prevent dimerization, hence blocking estrogen receptor signalling to targeted genes [ 23].

But now, McGurty said, the two factions appear to be uniting against a level of deregulation unseen since the agency was founded, in 1970.

What level of deregulation is required before the histology becomes abnormal?

In other words, the data presented here reveals that both luminal subtypes are characterized by the same epigenetic driver patterns, only differing in the level of deregulation.

In all but two cases, a significant activation in mutant roots only occurred in response to another LCO or LCO combination as in the wild type, probably indicating some level of deregulation in the symbiotic mutants (Fig.  3).

But since non-adverse influences, such as eating or a change of culture media, can also lead to purely adaptive responses in 'omics' studies which may come close to the level of deregulation seen after drug treatment it is inappropriate to interpret any drug-induced change in expression as an adverse effect.

Further qRT-PCR analysis of two strong E2F target genes, DHFR and cdc6, showed similar levels of deregulation in both Rb-deleted and un-phosphorylated ΔCdk Rb-HA MEFs, whereas WT Rb-HA repressed both of these genes.

The database describes the association of over 6000 DNA copy number alterations; 8000 genes and their 30 000 transcripts and 22 000 proteins; and 279 miRNAs in pancreatic cancer as well as the observed levels of deregulation among a broad range of specimen and experimental types (Table 1).

Thus, from a purely epigenetic perspective, our data suggests that ER+ breast cancer consists of only two main epigenetic subtypes, which differ mainly in the level of epigenetic deregulation, and not in the specific deregulated genes or signalling pathways.

In order to quantify the level of miRNA deregulation within each of BRCAX subgroups, we have performed differential expression analysis comparing each subgroup to normal breast tissue.

This suggests that the level of Wnt deregulation required to transform the colorectal epithelium is higher than in the small intestine.