Sentence examples for level of critical effector from inspiring English sources

It is uncertain whether optimal clearance of viruses such as HSV-2 that cause a limited, non-systemic infection solely requires expression of effector functions by infiltrating CD8+ T lymphocytes, or if the clearance rate is reflective of the expression level of critical effector functions.

Because donor Tc2-like cells proliferated in vivo and infiltrated the infected genital epithelium similar to Tc1 cells, the diminished virus clearance by Tc2-like effector cells correlated with reduced expression of critical effector functions.

In sedentary animals we did not detect any changes in the total concentration of AMP or any other adenine nucleotides but we were not able to quantitate the levels of free AMP, the most critical effector of AMP kinase activation, and we postulate that the small fraction of total AMP that is in the pool of free AMP may have been increased leading to the activation of AMP kinase.

p21CIP1 is one of the critical effectors of p53 to induce a cell cycle arrest [23].

One of the critical effectors of c-Myc overexpression is the major mammalian tumor suppressor TP53.

These findings indicate that PU.1-mediated upregulation of CSF-1R is a critical effector of MLL leukemogenesis.

These results indicate that reduced Pttg2 levels induce inhibition of cell growth through p53-dependent p21 induction, and p21 appears to be a critical effector of shPttg2-induced cell death.

Zap70 acts as a critical effector of downstream signalling after initial engagement of TCR.

The critical effector of HER2Δ16 tumorigenic properties is represented by SRC kinase.

GSK-3β is ubiquitously active and is a critical effector of PI3K/ AKT cellular signaling.

As Noxa has been shown to be a critical effector of apoptosis due to its ability to neutralize Mcl-1 [ 25, 33], we next assessed the expression levels of Noxa during the apoptotic death of the cells.