For this reason, the intracerebral inoculation of newborn mice with BTV vaccines has been used as an animal model to evaluate the level of attenuation of live attenuated BTV vaccines [28].
These results provide a second example of the difficulty in predicting the precise level of attenuation following import of an attenuating mutation into a different DEN serotype.
An alternative approach is to use live attenuated RSV; however, it has been difficult to achieve the appropriate level of attenuation for infants.
The maximum level of attenuation is evaluated from experimental data, rather than pure theoretical methods.
The achieved level of attenuation is also compared to the maximum level of attenuation of the global error that can be achieved based on the disturbance/secondary source arrangement.
A major hurdle for the development of LAIV exists in achieving the proper level of attenuation while maintaining immunogenicity.
Furthermore, a suboptimal distributed H∞ fuzzy controller with constraint is proposed to minimize the level of attenuation.
Even in the situations in which some level of attenuation on the tidal flats has been considered30,31,32,33,34, important modifications to the duration of inundation and its effects on vegetation have not been taken into account.
Despite their high level of attenuation in monkeys, the chimeras induced a moderate-to-high titer of neutralizing antibodies and prevented viremia in monkeys challenged with WN.
In the proposed structure a novel harmonic suppressed Wilkinson power divider used in DPA, which results in harmonic suppression with high level of attenuation.
