The architecture of the sites and the organization of the materials collected on each reveal a deep lacuna in the level of Internet access to research materials by and about Darwin.
Last year's Velázquez exhibition at the National Gallery featured several pictures that the painter had not completed; they had great lacunae or only one level of paint.
However, those resorption lacunae also indicated high level of resorption in the OA group.
Because bisphosphonates bind strongly to exposed bone mineral around resorbing osteoclasts, high levels of bisphosphonate in the resorption lacunae would remain even after several years.
The 'type of coverage' section was not part of the literature review because of the lack of internationally comparable studies conducted at this level – this is exactly one of the lacunae that will be addressed by our project.
Since the achievement of justice or democracy, for example, presupposes an effective political sovereign, the lacuna of sovereignty at the global level means that justice and democracy are necessarily incomplete and probably unattainable there.
A number of studies, including the current study identified lacunae in the STI/HIV knowledge and reflected low levels of awareness among adolescent girls.
DHMEQ significantly suppressed formation of osteoclasts in arthritic joints, and also suppressed expression of NFATc1 along the inner surfaces of bone lacunae and the eroded bone surface, while serum levels of soluble receptor activator of NF-κB ligand (RANKL), osteoprotegerin and macrophage colony-stimulating factor were not affected by the treatment.
Examination of peri-implant tissues for TRAP mRNA expression revealed a pattern similar to that of cathepsin K. TRAP mRNA was detected in mononuclear and multinuclear cells associated with both the bone surface and the polyethylene particles, although the message levels were notably higher in the cells located in resorption lacunae at the bone surface.
Nevertheless, it has been shown that bisphosphonates accumulate in bone (Lin et al, 1992), and that their effective local concentrations at sites of active bone resorption are much higher than serum levels, and may reach up to 10−3 in the resorption lacunae (Sato et al, 1991).
