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These authors reported clinical attachment level gains between 2.06 and 2.76 mm [19].
The optimization process modifies the amplitude of the original filters over the frequency band of interest without adding high level gains.
The percentage of the genome encompassed in higher level gains was not significant (p = 0.88), suggesting that it is not the proportion of DNA amplified but the number of amplification events that is most important.
CDKN2A/B deletion was also observed in Res259 astrocytoma cells, which also contained the well-described 4q12 amplicon, resulting in high level gains of the oncogenes PDGFRA and KIT, and low-level gain of a region including KDR/VEGFR2.
These measures included: the number of copy number changes i.e. gains, losses, higher level gains (>0.6 log2 amplitude) and total number of segments; the percentage of the genome targeted by copy number change (gain, loss and high level gain); and a "Hicks index" as described [31] for gains, losses and both.
Figures 5 and 6 showed the results of cytoband level gains and losses on DLBCL and MCL, respectively.
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Gov. Bob McDonnell of Virginia, the chairman of the Republican Governors Association, said that the state-level gains Republicans made in "provides optimism for the future".
He lost the state in 2012, and Republicans thanks in part to crafty redistricting in 2011 consolidated their state-level gains, winning supermajorities in both houses and electing Pat McCrory, the Republican former mayor of Charlotte, as governor.
High-level gains (amplifications) were defined as regions with a mean log2 CN ratio ≥0.22 for ≥3 contiguous SNPs.
Figure 8A shows the results of PGS genomic segmentation analysis in U2OS and MG63 cell lines, revealing a high-level gain of c-MYC in MG63 and no significant change in RECQL4, and low-level gains in c-MYC and RECQL4 in U2OS cells.
This increased frequency of alterations is true for losses, mutations and amplifications (high-level gains) but does not necessarily hold for low-level gains [ 24, 31].
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