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No p53 expression change has been documented in lymphocytes and, of course, in p53-null HL-60 cell line, where Puma level diminution was simultaneously detected.
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The BAT-gal treporter repofter of canonical Wnt signaling showed reduced but generally not absent signal in Pygo1/ Pygo2 mutant embryos, with tissue-specific variation in level of diminution.
This parameter exhibited a greater level of diminution at the 10 and 20% dose in respect to 5% dose treatments (Table 1).
In a primary glomerulopathy study, the urinary uPA levels were significantly reduced by intraglomerular fibrin deposition, which suggests that a decrease in urinary uPA levels and diminution of isolated intraglomerular plasminogen activator activity contribute to disease progression [ 14].
The decrease of urinary uPA levels and diminution of isolated intraglomerular plasminogen activator activity contribute to the progression of primary glomerular diseases [ 14].
Thus, in the limb bud, where Shh acts principally to de-repress target genes by lowering Gli-R levels, a diminution of Gli-R should lead to a gain of function phenotype.
basilicum L). inoculated by Gigaspor arosea and Gigaspora margarita induce a quantitative and not qualitative variation in the essential oil constituents, with an increase in oxygenated monoterpene level and the diminution of hydrocarbon sesquiterpenes.
P-gp has been implicated in cellular resistance to anticancer drugs, which is believed to be originated in a lowering of the concentration of many anticancer drugs in tumor cells, although the level of the diminution due to the P-gp action itself remains unclear [ 3– 5].
MIC (minimum inhibitory concentration) values were determined visually as the lowest concentration of drug that caused significant growth diminution levels (≥ 50%).
The BAT-gal transgene reporter of canonical Wnt signaling showed reduced levels of expression in Pygo1-/-/ Pygo2-/ mutants, with tissue-specific variation in degree of diminution.
We previously reported that there are considerable differences in the levels of GH in males and females in response to caloric restriction, i.e. females show increased GH levels whereas males show dramatic diminution of GH levels [10].
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