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On average, those in the combination group gained 5 letters of vision, compared with a loss of 8 letters of vision in the PDT-only group.
There were no subjects who lost more than 15 letters of vision.
24% in the combination group and 5% in the PDT-only group gained at least 15 letters of vision.
Study results showed that 15.38% of subjects gained at least 15 letters of vision by month 6.
During the third year, 8/161 (5%) subjects lost 20 or more letters of vision, and five of these fully or partially improved in subsequent visits.
In addition, 41% of the 0.5-mg-treated group and 34% of the 0.3-mg-treated group gained at least 15 letters of vision, compared with only 6.3% in the PDT-treated group.
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Literary scholar Paul Keen has described the Republic of Letters as a vision of society in which "all rational individuals could have their say, and in which an increasingly enlightened reading public would be able to judge the merit of different arguments for themselves".
The traditional clinical measurement of vision, Snellen letter visual acuity, can provide an inadequate measure of forward light scatter relevant to glare effects in adult subjects.
In addition, 56.3%% of patients had gain of vision of ≥5 letters; 25.0 % of those patients with VA of ≥20/40 also had gain of ≥5 letters.
Among his other works are A Review of Berkeley's Theory of Vision (1842) and Letters on the Philosophy of the Human Mind, 3 vol. (1855 63).
There were eye charts superimposed on each photograph, not the usual mix of letters for checking vision, but some sort of text.
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