Finally, recent studies have shown that LIN-28 may recognize the pre-let-7 loop nucleotides and block the processing of human pri-let-7 RNAs into mature miRNAs in embryonic stem cells, suggesting that pre-miRNA loops may be recognized by LIN-28 or LIN-28-like RNA binding factors that control mature miRNA biogenesis [23] [25].
It is possible that Sox2-Lin28 protein complexes may mediate a variety of biological process in the nucleus, potentially including the processing of let-7 miRNA.
Lin28 disrupts the processing of let-7 miRNA in both the cytoplasm and nucleus [29], [30].
Furthermore, miR-125b can regulate a downstream target, lin-28 homolog B (LIN28B), in HCC cells, and subsequently indirectly promote the processing of let-7.
When present in the nuclei of tumor cells, TRAIL-R2 inhibits the processing of the primary let-7 miRNA (pri-let-7) via interaction with accessory proteins of the Microprocessor complex.
TRAIL-R2 was found to associate with components of the large Microprocessor complex inhibiting the processing of pri-let-7 miRNA.
Without loss of generality, let the current processing section be the j th section of the image, and create a polynomial of degree r – 1 as follows: f j x = a 0 + a 1 x + a 2 x 2 + … + a r − 1 x r − 1 mod 257.
Unlike Lin-28, which specifically regulates let-7, the NF90/NF45 complex may be more promiscuous, as the processing of 3 other analyzed miRNAs is also modulated.
Consistently, the processing of two other miRNAs bearing conserved loops, miR-101 and let-7a-1 is also prevented by complementary looptomiRs (Fig. 3) [ 114].
Evaluators lets instructors generate games from collections of exercises addressing basic concepts about the design and implementation of computer languages (in particular, the processing of artificial languages according to the model of attribute grammars).
