Such energy regulation of GABAA receptor function could contribute for example to the well-known heightening of alertness by hunger in contrast to the relative lethargy induced by satiety: hunger cuts down ATP supply, thereby inducing GABA-current rundown and decreasing inhibitory CNS neurotransmissions mediated by long β2 isoform-containing GABAA receptors.
The marked respiratory depression and lethargy induced by SKF97541 and baclofen but not by lesogaberan and 3-APPiA we observed are consistent with the known susceptibility to uptake of these compounds.
The bulk of the HHMI grants will fund molecular research on basic cell biology and studies of parasites, such as Trypanosoma cruzi (which causes the lethargy-inducing Chagas' disease) and Escherichia coli (a cause of fatal childhood infections in poor countries).
These drugs are agonists at γ-aminobutyric acid receptors, inhibiting the release of neurotransmitters and reducing muscle tone, but drowsiness, ataxia, and lethargy are induced as adverse effects and may result in prolonged sedation and muscle relaxation.
Lethargy is induced at temperatures between 13 and 15°C (55 and 59°F).
Because most psychotropic drugs do induce lethargy, drowsiness, and fatigue, e.g., Physician's Desk Reference 1126, 1236, 1640, 1755, 1788, 1883 (43d ed.
There's no pleasure in revealing the only spoiler here: Despite slick cinematography, "Murder 3" induces more lethargy than thrills.
These drugs were developed for the treatment of conditions such as schizophrenia, not dementia, and are generally intended for young, robust patients; when such medications are given to the frail and the elderly, they induce a lethargy that can mask symptoms of other afflictions.
Mr. Hall spent 20 minutes at the summit, but shortly after he began his descent he was struck by a severe form of high altitude sickness, cerebral edema: a swelling of the brain that induces crippling lethargy, hallucinations and other symptoms.
This class of drugs, which includes Abilify, Thorazine, and Risperdal, can induce fatigue, lethargy and weakness, sometimes resulting in leg cramps.
The caffeine might counteract pancake-induced lethargy.
