Sentence examples for lethality with this from inspiring English sources

Furthermore, other NQO1+ overexpressing cancer cells, such as A549 non-small cell lung cancer cells, showed synergistic lethality with this combination treatment.

When Igf2 +m/−p has been previously combined with genetic models of tumour susceptibility, including several developmental genes, there has been little evidence for combined lethality with this allele, suggesting that the synergistic lethality phenotype we now describe with p53 is novel (Christofori et al, 1994; Hassan & Howell, 2000; Ho et al, 2009; Wu et al, 2006).

This result was consistent with previous genetic analysis of the genes encoding this complex (Fabre et al. 1995), indicating that the reported lethality with the Cre- loxP approach was likely due to tag-specific effects (Strawn et al. 2004).

The correlation of global lethality with the FDA approval numbers has mostly been present in previous years (Table S2).

However, more recently (2007) the cancer network has become correlated with local lethality, with the exclusion of pancreatic, liver, and esophagus cancers (Table S2).

Animals deficient for Sucla2 exhibited embryonic lethality with the mutant embryos dying late in gestation.

An analogous experiment with scrib RNAi could not be performed due to synthetic lethality with the Brm-DN transgene.

However, gene-trap disruption of the Gga2 gene resulted in either embryonic lethality with the BayGenomics (Byg) gene-trap or neonatal lethality with the Texas Institute for Genomic Medicine (Tigm) gene-trap (Govero et al. 2012).

We fed rapamycin, a TOR inhibitor, to larvae possessing the null allele of the α subunit and tested if this agent impacted the lethality associated with this mutation.

The mutation detected in the nuclear M protein, responsible for the resistance to amantadine compounds, similar to that found in the AH5N1 Hong Kong virus from 1997, caused concern due to the high lethality seen with this kind of strain, and because of the high infectivity of this new virus [ 8].

Notably, remobilization of insertion 01-0032, whicausesses an early recessive embryonic lethal phenotype as a result of disruption of the mouse Slc25a22 gene [ 4], restores activity of the gene and rescues the recessive lethality associated with this insertion as heterozygous 01-0032/footprint mice are phenotypically normal mice.