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Despite these paradoxic effects with the most lethal dose, lethality with the medium cell-wall dose was associated with progressive reductions in blood pressure and increases in heart rate, as would be expected in a state of sepsis.
The correlation of global lethality with the FDA approval numbers has mostly been present in previous years (Table S2).
However, more recently (2007) the cancer network has become correlated with local lethality, with the exclusion of pancreatic, liver, and esophagus cancers (Table S2).
Animals deficient for Sucla2 exhibited embryonic lethality with the mutant embryos dying late in gestation.
However, gene-trap disruption of the Gga2 gene resulted in either embryonic lethality with the BayGenomics (Byg) gene-trap or neonatal lethality with the Texas Institute for Genomic Medicine (Tigm) gene-trap (Govero et al. 2012).
An analogous experiment with scrib RNAi could not be performed due to synthetic lethality with the Brm-DN transgene.
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Thus, the degenerative phenotypes produced by Cox4 knockdown range from semi-lethality with the stronger, X-chromosomal elav-GAL4 driver (strain 458), to no detectable impairment within the first 2 weeks of adult life, for nrv2-GAL4.
A gene was included in the set of lethality genes with the following criteria: phenotype contains the word "lethality", the type of lethality annotation contains neither "partial" nor "wean".
To confirm that these mutations are indeed responsible for the synthetic lethality with rps15-1, we crossed the Ins9 and Ins15 strains to either the Δnhp2::kanMX4, rps15-1 or Δutp15::kanMX4, rps15-1 null mutants respectively.
The increasing familiarity and lethality with helium is partly the reason for the rise in suicide by helium [ 36].
When expressed with MS1096.Gal4, UAS.DN-Notch leads to significant lethality with 12% of the expected experimental flies observed (93 experimental compared to 659 siblings).
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