Sentence examples for lethality with a from inspiring English sources
This loss of interaction is relevant in vivo since we found that pol3-ct confers HU sensitivity on its own and synthetic lethality with a POL32 deletion.
The mutation results in early embryonic lethality with a subpenetrant phenotype of kidney agenesis.
Targeted disruption of murine Cdk2ap1, an inhibitor of CDK2 function and hence G1/S transition, results in the embryonic lethality with a high penetration rate.
We have shown here that Hira-mutants in young males lead to a higher paternal-effect embryonic lethality with a phenotype of chromatin bridges.
Here, either through a random screen or starting from an educated guess, we have looked for mutations causing synthetic lethality with a thermosensitive allele of RPS15 to find genetic interactors potentially involved in nuclear export.
It is a disease of insidious progression and high lethality, with a 5 year survival rate of only 6%.
In addition, we found a synthetic lethality with BUD23, a gene encoding a methyltransferase involved both in rRNA modification and small subunit nuclear export.
Consistent with a potential role of LGR in morphogenesis, LGR5 knockout mice show 100% neonatal lethality with ankyloglossia, an abnormal craniofacial morphogenesis characterized by the fusion of the tongue to the floor of the oral cavity.
The demonstration of synthetic lethality with ATM in a cisplatin treatment model suggests that aberrant or reduced ATR signaling leads to the generation of collapsed replication forks in S-phase and the activation of ATM-dependent signaling and S-phase arrest.
Anp32b-deficient mice demonstrated a strain-dependent penetrance of perinatal lethality with surviving mice in a genetically mixed background showing growth defects, premature aging, and a wide array of pathologies 101.
To look for potential genes that act as pha-4 regulators, the Mango lab previously conducted two screens for suppressors of the lethality associated with a partial loss of pha-4 activity.
