Sentence examples for lethality which has from inspiring English sources

However, knockdown of Adam17 results in multisystem developmental defects and perinatal lethality, which has made study of the role of Adam17 in specific cell types difficult.

In mouse (Kawamura et al., 2012) and Caenorhabditis elegans (Kinchen et al., 2008; Skorobogata and Rocheleau, 2012) rab7 null mutants cause embryonic lethality, which has so far precluded the analysis of neuronal phenotypes.

Global deletion of the gene encoding BDNF leads to early post-natal lethality, which has made the study of BDNF's role in the adult nervous system more difficult (Carroll et al., 1998).

The P insertion chromosome is lethal over Df 3L fz-GF3b/TM6b (which has a deletion of the 70C1-2; 70D4-5 region), supporting the view that the P insertion was responsible for lethality.

Despite its lethality, IBC remains poorly understood which has greatly limited its therapeutic management.

The non-contact group was found to have a significantly higher level of suicide intent and tended to choose carbon monoxide poisoning by charcoal burning which has a high lethality.

However, this allele does not induce the lethality observed with Df 3R BSC56, suggesting that either cdc16 is not the relevant gene or the allele we tested, which has not been extensively characterized, still produces sufficient active protein that allow embryonic development.

These findings are further supported by their recent research in Plu1 knockout mice, which have the phenotype of neonatal lethality and neural defects [ 148].

Synthetic lethality is an appealing technique for selectively targeting cancer cells which have acquired molecular changes that distinguish them from normal cells.

In contrast to SAFB1−/− mice, which have major phenotypes, including prenatal and neonatal lethality, growth retardation and fertility problems, there were no gross phenotypes in SAFB2−/− mice.

These deletion strains all suppressed BRCA1 lethality (Fig. 2A) and similar to isogenic dhh1Δ and ccr4Δ strains, which have a checkpoint adaptation function [8] [12], deletion of SPT4 suppressed the prolonged G1 arrest induced by expression of BRCA1 (Fig. 2B).