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Estimates of embryonic lethality were extracted by the image analysis algorithm DevStaR, which was developed to recognize C. elegans developmental stages for this specific application (White et al., 2013).
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A synthetic lethality (strong negative genetic interaction) network was extracted from BIOGRID, version 2.0.60 [31].
Although this so-called centrality-lethality rule had been questioned in the past [ 26, 27], no clear conclusions could be extracted.
On the other hand, a high lethality was found in the extracts of the gorgonians Pacifigorgia adamsii (68%), Muricea sp. (83%), the tunicate Polyclinum laxum (96%) and the echinoderms Toxopneustes roseus (96%), Isostichopus fuscus (96%) and Pharia pyramidata (93%) (Table 1).
In our present study the stem extracts did not display any anticancer potential while in case of fruit, the most prominent lethality was shown by the chloroform and n-hexane extracts with an LC50 4.52 and 3.49 μg/ml respectively which is comparable to the standard drugs 5-florouracil and vincristine with 50%% lethality at 5 μg/ml and 8.1 μg/ml respectively.
The degree of lethality was found to be directly proportional to the concentration of the extract.
No lethality was observed during the 42-day period of treatment with D. reticulata extract.
The group's lethality is undeniable.
The Las Vegas massacre has already — astonishingly, given its extraordinary lethality — been largely removed from our minds.
The threshold for lethality was determined with renal absorbed dose and injected activity as indicators.
Lethality was observed between days 2 4 after intoxication.
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