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An expressive difference in the predicted lethality was observed between the classic approach and the proposed model.
At the same time, in the control group of animals, lethality was observed in 11% of cases, and suppurative complications were observed in 100% of cases.
The result showed that the LD50 value of BtOH and EtOAc fractions could not be determined as no lethality was observed up to 40 g/kg (p.o). in mice.
Lethality was observed between days 2 4 after intoxication.
No lethality was observed in Dcas1/+ embryos (n = 613).
When the shRNA was ubiquitously induced by EIIa-Cre driver, embryonic lethality was observed.
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Lethality is observed in a high proportion of heat shock treated embryos over-expressing menin [16].
In some cases homozygous lethality is observed which is most likely due to second mutations on the chromosome.
Lethality is observed with W557S, but not the C-terminal truncation, suggesting lethality is not due to loss of domain function.
No deaths occurred when intoxicated mice were treated with 80 µg of polyclonal goat anti-ricin antibodies by 6 h post-intoxication (Fig. 4B) but about 30% lethality were observed when antibodies were applied at 7 h post-intoxication.
Unlike SEC-23, which is involved in the general secretory pathway and affects cuticle secretion in a gross manner leading to lethality, CHE-14 appears to be involved in the select secretion of apical membrane components since lethality is observed at a very low penetrance in che-4 mutants [10].
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