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We found late-acting lethality to be considerably more effective than early-acting lethality.
The genotyping we performed on both necrotic and non-necrotic seedlings showed 'Type 1' lethality to be linked to two loci, one mapping to LG5 of PEAR3 and one to LG1 of 'Moonglow', with one quarter of all the possible genotypic combinations at these two loci being mainly represented by 'Type 1' seedlings (Table 2).
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There might be additional synthetic lethalities to be discovered and exploited in future.
The mechanism of synthetic lethality appeared to be due to the re-induction of senescence.
However, the lethality appears to be independent of demethylase activity, with UTX-1 instead primarily being required for formation of the UTX-1/SET16 H3K4 methyltransferase complex [ 114].
Similarly, cisplatin induces interstrand cross-links that are repaired by interstrand cross-link repair pathways that are also cell cycle-dependent, and their contribution to cisplatin lethality needs to be quantified.
However, as it is an alkylating agent, its lethality to cells is via the formation of DNA interstrand cross-links.
This "guarantee of lethality" may have to be momentarily put on hold, however, after desktop-manufacturing company Stratasys notified the collective that their business was no longer welcome.
Since GABA is an inhibitory neurotransmitter, the lethality was thought to be due to neuronal changes [17], [20], [21], [38].
The lethality is thought to be due to defects in the apical terminal web of the gut epithelium, a tissue that expresses only ezrin.
The degree of lethality was found to be directly proportional to the concentration of samples.
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