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By contrast, p65 knockout mouse exhibit early embryonic lethality resulting from extensive hepatocyte apoptosis [26], [27].
Tagged SUMO rescues the lethality resulting from sumo mutations (data not shown) demonstrating the functionality of the tagged protein.
These results indicate that the lethality resulting from deletion of SLD1 is not due to loss of SBM2, but that mutation of SBM3 produces a more severe phenotype than does deletion of SLD2.
For example, perinatal lethality resulting from a severely compromised epidermal differentiation program and dysfunctional EPB results when native Cldn6 is expressed at high levels [16]; while with lower levels of expression, less severe defects occur with the capacity for normalization of EPB function [15].
They report that widespread apoptosis correlates with the embryonic lethality resulting from this homozygous Δ11 Brca1 mutation.
Our results suggest that down-regulation of splicing pathway enhances the phenotypes caused by defects in RNA regulation but not embryonic lethality resulting from disruption of cytoplasmic dynein.
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This result suggested that embryonic lethality resulted from the lack of functional Noc4l alleles.
To check whether lethality resulted from a lack of vinculin-mRNA transcription from the VCL-ΔIn20/21-allele VCL-ΔIn20/21-allele VCL-ΔIn20/21-allelesolated from E10.5 embryos of the different genotypes.
17 No lethality resulted from dose-dependent toxicity in monkeys that received single BMTP-11 doses up to 100 mg/kg.
In contrast, the C96-Gal4 dictatesicthees the RNAi expression along the wing margin, thus minimizing a potential effect of embryonic lethality resulted from RNAi overexpression by the dpp -Gal4 driver.
Only subsequently did it become evident that this lethality resulted from a requirement for IFT in Hh signalling, and that this was impacting tissues beyond the node (Huangfu et al., 2003).
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