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The report further puts the lethality of various substances in perspective: .
Glutamine or glucose deprivation also results in synthetic lethality of various antitumor cell phase specific compounds.
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For each construct, each of the lines used showed the same patterns of lethality under control of various drivers.
The specific role of Trp53 in rescue of embryonic lethality of mice with various Brca1 mutations remains unclear.
Over the past years the physiological and biochemical properties of the single yeast APC isoform Sal1p (suppressor of ∆ aac2 lethality) as well as of various mammalian homologs became more and more clarified [ 8].
A pioneering study by Chen et al (2010) found that many new genes rapidly evolve essential functions in Drosophila, as the knockdown of expression many of these new genes by RNA interference (RNAi) leads to lethality at various stages of Drosophila development [ 21].
For example, genetic deficiencies in TGF-β1,2,3, TGF-β RI,II,III, Smad2, Smad4 and others (Oshima et al., 1996; Bonyadi et al., 1997; Larsson et al., 2001; Brionne et al., 2003; Andrews et al., 2006) all cause embryonic or neonatal lethality, due to the abnormal development of various organ systems.
In mouse lethality assays, various 50% lethal dose (LD50) were observed among 7 groups of isolates from liver aspirates.
The variation in time point and penetrance of embryonic lethality could be a consequence of different genetic backgrounds of various Brca1 mouse strains.
Its great lethality had led to several randomized trials of the administration of various types of immunotherapy.
The generation of various Kidins220-deficient lines will allow us to bypass the problem of early lethality, and permit an in-depth analysis of the functions of this protein during postnatal development and in adulthood.
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