In neonatal versus adult rats, the acute lethality of the type II pyrethroid deltamethrin was 16-fold greater in young animals (Sheets et al. 1994).
This hypothesis of segment duplication, associated with lethality of the type of gamete containing the duplicated segment in heterozygous configuration is also consistent with the observed allelic pattern and allelic frequencies and is in agreement with meiosis configurations.
The high rate of de novo mutations in SMN1 may account for the high carrier frequency in the general population despite the genetic lethality of the type I disease.
The tragedy in Colorado demonstrated the devastating lethality of AR-15 type guns, like the one used in the Aurora shooting, and has caused many to question whether it makes sense to allow the purchase of military-style assault rifles.
A gene was included in the set of lethality genes with the following criteria: phenotype contains the word "lethality", the type of lethality annotation contains neither "partial" nor "wean".
The genetic interaction data set was processed by retaining only those entries in the interactions file that are denoted as 'Manual curation' and of type 'Synthetic Lethality' or 'Synthetic growth defect'.
Using a bench-to-bedside approach, we have implemented a mouse model of pneumonia and found that RNA abundance profiles obtained from blood samples taken prior to appreciable mortality were able to distinguish between the two variables tested in the assay: lethality of the insult and type of infectious agent.
Nevertheless, in all three experiments, the timing of expression of 'Type 1' and 'Type 2' lethality was the same.
The different timing of the expression of 'Type 1' and 'Type 2' lethality indicated that they were caused by two independent postzygotic incompatibilities.
As shown in Fig. 2b, Ot B treatment suppressed the lethality of heat stress in wild-type C. elegans.
