Sentence examples for lethality of two from inspiring English sources

Here, we extend our earlier findings by demonstrating embryonic lethality of two lines of mice carrying null alleles of Lrp1b.

(Lethality of two or more mutations is assumed because it greatly facilitates the calculations).

AtNUP62 is an essential gene, as demonstrated by the lethality of two out of four T-DNA insertions [ 15].

This conclusion is supported by the similar early lethality of two further PU.1-knock-down mouse models (Sfpi1 Blac/Blac and Sfpi1 BN/BN mice, expressing 2%and20%0% of the wild-type PU.1 protein, respectively) generated by inserting a LacZ expression cassette into exon 1 of Sfpi1 (42).

Take, for instance, "Under Air," about the everyday lethality of one of oil drilling's byproducts, hydrogen sulfide.

The disease is fatal in less than 1% of European subtype TBE cases, but the lethality of the two Eastern TBEV subtypes is much higher [ 1].

Our findings argue strongly that the well-known mutual exclusivity of KRAS and EGFR mutations in LUAD is due to synthetic lethality of the two mutant oncogenes, rather than to functional redundancy.

To confirm the synthetic lethality of the two PS1-hp mutants when both are integrated in the genome, CRY119 (mcm4 -HA K658A:: TRP1 integrated as a partial duplication at the mcm4 locus) was mated to RSY1345 (mcm5 -HA K658A:: URat athehe ura3 -1 locus) that also had a mcm5 :: KanMX4 deletion to form diploids, which were then sporulated.

Likewise, overexpression of BCY1, which negatively regulates PKA, also rescued the Ts lethality of all three spc24 mutants (Toda et al. 1987).

Collectively, these results suggest that lethality of the three lincRNAs observed in this study are likely not due to cis or enhancer-like RNA regulatory effects.

Synthetic lethality refers to the lethal combination of two independently viable mutations and is well studied in model organisms such as the budding yeast.