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Despite the fact that lines with a recessive lethality of more than 92% were generally subjected to the allelism test, there is an increasing level of difficulties and ambiguity in determining the identity of mutations with decreasing lethality.
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Under constitutive expression with the antitoxin component on the plasmid and the toxin on the chromosome, the lethality of the more stable toxin is mediated by the unstable antitoxin.
(Lethality of two or more mutations is assumed because it greatly facilitates the calculations).
The JJ1549 strain has a background of embryonic lethality of only 6% more than the wild-type (see Results section) and thus it is a good strain to use in synthetic genetic screening for embryonic lethality.
Social anxiety disorder in schizophrenia is associated with a higher lifetime rate of suicide attempts, greater lethality of suicide attempts, more past substance/alcohol abuse disorder, lower social adjustment, and overall quality of life [ 19].
After the first round of feeding, we repeated the 70 with the strongest apparent enhancement of lethality twice more.
The results obtained here indicate that STAT6-dependent reduction of lethality compromises more than the IgE-mast cell axis, and must be related with a more profound disruption of IL-4-driven Th2 response in the CF mouse but also affecting CF lung disease in humans.
As we saw in Boston where the attackers fashioned a pressure cooker into a bomb the lethality of explosives is now more contained, compared to the damage bombs caused prior to and including the 1994 Oklahoma City attack.
Black folk didn't need the A12 weekend's reminder of white supremacist lethality any more than we needed the advent of cellphone footage to know police fear, beat, and shoot us with impunity.
One of the problems connected with transgene overexpression is putative cytotoxicity, sometimes associated with induced lethality, but more frequently silencing of transgene expression and counter-selection of cells with low or no transgene expression.
This can explain the steady increase in lethality of duplications because they cause more severe overexpression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com