Sentence examples for lethality of animals from inspiring English sources

Finally, knockdown of lipocalin-related protein gene lpr-5, which is involved in intercellular signaling, and cuticular collagen gene dpy-7, structural component of the cuticle, by RNA interference (RNAi) resulted in increased lethality of animals after MeHg exposure.

This may eventually lead to severe deterioration of the nervous system and the premature lethality of animals.

Infection by the oral route can limit the virulence of JUNV and smaller percentages (40 60% versus 100% lethality) of animals succumb to infection versus parenteral routes [ 295].

Notably, we also observed a deficiency in the frequency of 'A' homozygous animals, which is also consistent with previously documented patterns of inheritance in P. microlepis, specifically, early lethality of animals homozygous for the dominant allele [ 14, 19].

Although complete deficiency of ILK confers lethality, analysis of animals with moderately reduced levels of ILK or other components of the integrin-signaling complex has revealed a novel function in aging.

To measure possible embryonic lethality of KO animals, timed matings were conducted using Het parents.

Consistent with the assumption of embryonic lethality of homozygotes, animals homozygous for the mutant allele were absent in the genotyped sample (P = 3.56 × 10−5).

Although conventional Brca1 mouse models have enabled us to learn a lot about the biological functions of BRCA1, the observed embryonic lethality of homozygous animals and lack of mammary tumour development in heterozygous mice made it difficult to study the role of BRCA1 in tumour suppression.

Because of the embryonic lethality of homozygous animals carrying two defective Brca1 alleles and the lack of mammary tumour development in heterozygous mice carrying one defective and one wild-type Brca1 allele, these models could not be used to study the role of BRCA1 in tumorigenesis.

Subsequent knock-in of this mutation in the mouse Ttn gene demonstrated embryonic lethality of homozygous animals due to severe defects in sarcomere assembly, while heterozygous mice are viable and develop DCM when exposed to cardiac stress (Gramlich et al, 2009).

Because of the increasing incidence and high lethality of melanoma, animal models for continuously observing melanoma formation and progression as well as for testing pharmacological agents are needed.