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cpl-1 (a cathepsin L cysteine protease) mutants are embryonic lethal and defective in yolk processing, but lethality may be due to yolk platelet aggregation in the cytoplasm rather than an energetic requirement for yolk [25].
Second, male embryonic lethality may be due to improper development of extraembryonic derived tissue, potentially resulting in placental failure or incomplete chorioallantoic fusion.
Further, DSIF and other conserved suppressors of BRCA1-induced lethality may be grouped into a temporally linked mRNA signaling/decay pathway that responds to DNA damage encountered by RNAPII in actively transcribing genes at the elongation stage of transcription (Fig. 6E).
Therefore, recombinant allele lethality may be the cause and a hypothetical model for its action was developed.
Its lethality may be due to difficulties in detecting it at an early stage and lack of effective treatments for patients with an advanced or recurrent status.
Recessive lethality may be one reason, but it cannot be the explanation for all heterozygous regions, which account for more than 30% of the genome.
Similar(49)
Genes differentially-expressed between sensitive and resistant strains show functional homogeneity: dioxin-lethality may be associated with broad dysregulation of entire pathways, not just single genes.
Due to the purpose of a study, a small spontaneous lethality rate may be essential especially when the authors are aiming for EC10 instead of EC50.
(97, 98) Taking advantage of the dysregulated DNA damage response in cancer using the synthetic lethality approach may be one of the most promising prospects for the future of cancer treatment.
As such, the centrality-lethality rule may be misleading.
However we have been unable to determine the basis for the lethality but it may be associated with a reduced vigor or failure to compete for material support.
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